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Structure of DNA (deoxyribose nucleic acid) Chemistry Tutorial
Nucleic acids are the carriers of genetic codes in living things.
The two principal types of nucleic acids are deoxyribose nucleic acid (or deoxyribonucleic acid, DNA) and ribose nucleic acid (or ribonucleic acid, RNA).
DNA is a
Individual monomer units are called nucleotides.
The DNA polymer is composed of:
(i) a backbone of molecules of the
sugar deoxyribose (a 5 carbon sugar)
(ii) phosphate groups linking the deoxyribose sugar molecules together in a chain
(iii) four principal bases (2 are pyrimidines and 2 are purines):
⚛ cytosine, a pyrimidine, abbreviated to C
⚛ thymine, a pyrimidine, abbreviated to T
⚛ adenine, a purine, abbreviated to A
⚛ guanine, a purine, abbreviated to G
The Watson-Crick model of DNA is that of a double helix of two long DNA molecules held together by
In this "double strand" of DNA, the principal bases occur in pairs with hydrogen bonding between them:
⚛ thymine-adenine pair formed by 2 hydrogen bonds
⚛ cytosine-guanine pair formed by 3 hydrogen bonds
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Deoxyribose is a 5 carbon
sugar molecule and forms the backbone of the DNA polymer chain.
One of the four principal bases shown below can attach to this deoxyribose sugar molecule.
base attaches through its nitrogen to the carbon in the ring that is bonded to both the oxygen atom of the ring and an OH (hydroxy) group.
A phosphate group can link 2 deoxyribose sugar molecules by attaching through the other 2 available OH (hydroxy) groups.
These three components:
a deoxyribose sugar
a phosphate group
make up a DNA monomer or nucleotide.
These nucleotides link up to form the DNA polymer.
Representing a DNA Polymer Strand
The diagram below shows a piece of a strand of DNA:
The sequence of bases shown from top to bottom is:
The sequence of phosphate groups and deoxyribose sugars is always the same, only the sequence of bases changes.
It is common to therefore represent a strand of DNA using lines to represent the sugar-phosphate backbone, and the letters A (adenine), C (cytosine), G (guanine), and T (thymine) to represent the bases, as shown in the example below:
Double Stranded DNA
In a double strand of DNA hydrogen bonds occur between pairs of bases:
guanine is hydrogen bonded to cytosine
3 hydrogen bonds are formed
adenine is hydrogen bonded to thymine
2 hydrogen bonds are formed
Since the sequences of bases on one strand determine the sequence of bases on the other strand, the two strands are referred to as complementary.
The diagram below shows how a piece of uncoiled double stranded DNA could be represented.
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